![]() ![]() The environmental fate of non-steroidal anti-inflammatory drugs (NSAIDs) in the urban water cycle is still uncertain and their status is mainly assessed based on specific water components and information on human risk assessments. It can be used for chronic migraine prophylaxis as well, along with other medications such as beta blockers, antidepressants, and anticonvulsants. Naproxen is considered a firstline abortive medication for acute migraines. Offlabel uses of naproxen include the treatment of acute migraines and migraine prophylaxis. Diseasemodifying antirheumatic drugs (DMARDs) have become the firstline treatment for inflammatory arthropathies, and NSAIDs such as naproxen are used as adjunctive treatments. ![]() While naproxen and other NSAIDs are approved for the treatment of inflammatory arthropathies such as rheumatoid arthritis and ankylosing spondylitis, they do not alter the course of the disease nor do they prevent joint and soft tissue destruction that are common sequelae of these diseases. It is the firstline treatment for acute gouty arthritis, osteoarthritis, musculoskeletal pain and inflammation and dysmenorrhea. Naproxen is FDAapproved for the treatment of acute gout, ankylosing spondylitis, bursitis, polyarticular juvenile idiopathic arthritis, osteoarthritis, tendonitis, rheumatoid arthritis, pain, and primary dysmenorrhea. Naproxen was initially approved in 1976 for prescription use only and remained a prescription drug until it was approved as an overthecounter (OTC) medication in 1994. ![]()
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